If you are an X-Men fan you would always wonder what if mutants relly exist, but for your surprise mutants do exist. Yes, they do between us, actually, mutation, the term means a variation in the genomes, which causes permanent changes. However, in all the reported cases, the extreme mutation has not been a gift like shown in the movie but in fact, it comes as a curse. Here is a list of 10 most fierce mutation found in humans
Remember, Amitabh Bachchan’s Paa, yes the disease that caused Oro to be aged so rapidly. The disease actually a mutation, which accelerates the aging. The mutation is quite rare and it happens on a rate eight per million births. Most children who have progeria die of diseases, which mostly happen due to old age like a heart attack or stroke. . Most of the kids live around the age of 13, but some can live into their 20s.
This mutation affects the LMNA gene, a protein that provides support to the cell nucleus. The kids affected by progeria also shows symptoms like rigid (sclerotic) skin, full body baldness (alopecia), bone abnormalities, growth impairment, and a characteristic “sculptured” nasal tip.
2. Uner Tan Syndrome
Uner Tan syndrome is basically a mutation which takes the patient in the backward stage in human evolution. The people who suffer from the syndrome walk on all fours. Th syndrome was discovered by the Turkish evolutionary biologist Üner Tan after studying five members of the Ulaş family in rural Turkey. These individuals walk with a quadrupedal locomotion, use primitive speech, and have a congenital brain impairment (including “disturbed conscious experience”).
Also known as “werewolf syndrome” or Ambras syndrome, it causes excessive facial hairs as well as hairs on shoulders and ears. It affects as few as one in a billion people; and in fact, only 50 cases have been documented since the Middle Ages.
It happens due to a disruption of the “crosstalk” between the epidermis and the dermis as hair follicles form in the 3-month fetus at the eyebrows and down to the toes.
4. Epidermodysplasia Verruciformis
It is an extremely rare disorder which make humans an easy target of widespread human papillomavirus (HPV) infection. This infection causes scaly macules and papules (cutaneous squamous cell carcinomas) to grow on the hands, feet, and even face. These skin “eruptions” appear as wart-like lesions — and even wood-like and horn-like growths — with reddish-brown pigmented plaques. Typically, the skin tumors start to emerge in people between the age of 20 and 40, and the growths tend to appear on areas exposed to the sun.
5. Severe Combined Immunodeficiency Disorder (SCID)
Also known as the Boy in the Bubble Disease, it’s a disorder in which individuals are born without an effective immune system. The disease was made famous by virtue of the 1976 film, The Boy in the Plastic Bubble, a story inspired by the lives of David Vetter and Ted deVita. In the movie, a boy is forced to live in plastic isolation for fear of exposure to unfiltered air and the introduction of life-threatening pathogens. In real life, Vetter lived in this condition for 13 years, but he died in 1984 following an unsuccessful bone marrow transplant (a failed attempt to help him fight infections).
6. Lesch–Nyhan Syndrome
It affects one in every 380,000 births, nearly all of them boys. It results in an overproduction of uric acid — a waste product of normal chemical processes that’s found in blood and urine. But individuals with Lesch-Nyhan release excess uric acid through their blood which builds up under the skin causing gouty arthritis. It can also cause kidney and bladder stones.
Formerly known as “lobster claw hand, ”individuals with this disorder have a cleft where the middle finger or toe should be. These split-hand/split-foot malformations are rare limb deformities which can manifest in any number of ways, including cases including only the thumb and one finger (typically the little finger or little finger). It’s also associated with hearing loss. Genetically speaking, it’s caused by several factors, including deletions, translocations, and inversions in chromosome 7.
8. Proteus Syndrome
In conjunction with neurofibromatosis type I, this is the disease that likely afflicted Joseph Merrick, the so-called Elephant Man. It’s a condition in which bones, skin, and other tissues are overgrown. Individuals typically have organs and tissues that grow out of proportion with the rest of their body, and because the overgrowth varies and exhibits no apparent order, it can result in strange and imbalanced features. Signs of the disorder don’t usually appear until about 6 to 18 months after birth. The severity of proteus syndrome varies from individual to individual, and it occurs in less than one in one million people. And in fact, only a few hundred documented cases have ever been reported.
This genetic disorder is so rare that its rate of incidence is not even known. But it’s very obvious when someone with trimethylaminuria is standing next to you. Individuals with the condition, because they cannot break down the naturally occurring — but pungent smelling — trimethylamine, literally smell like rotting fish, rotting eggs, garbage, or urine. It’s for this reason that it’s also called the Fish Odor Syndrome. Trimethylaminuria is found in sweat, urine, exhaled breath, and other bodily secretions. But for individuals with this disorder, typically women (for unknown reasons) it shows up in abnormal amounts. The severity of the odors seem to peak just before and during menstrual periods and after taking oral contraceptives; there may be a link to female sex hormones like progesterone or estrogen.
10. Marfan Syndrome
This genetic disease is fairly common, a disorder of the connective tissues, and it appears in about one in every 10,000 to 20,000 births. Interestingly, nearsightedness (or myopia), is a common form of the disease. But it’s more renowned for the way it causes bones to overgrow and create loose joints. People with Marfan Syndrome tend to have long and thin arms and legs. Overgrown ribs can cause the chest bone to bend inward or push outward. Spinal curvature is another problem.